No doubt ketamine is the most proven and effective treatment to treat depression. Many studies have shown the potential of intravenous ketamine in improving the symptoms of depression in about 70% of individuals.
While ketamine IV infusions have remarkably known as the ‘gold standard’ in terms of administration, latest studies also discovered some other administration routes including sublingual, intramuscular and intranasal.
This administration route has raised some concerns because the administration rate is not as precise as needed for comfort and safety. In this process, ketamine absorbs quite rapidly into patient’s
There are so many wonderful people in this world who miserably struggle with chronic depression. Studies show, that the effects of depression for each person are different. Oftentimes, what treatment works for one, may not work for another.
You must have seen how debilitating effects of depression take away pleasure from patients’ daily lives.
It may also cause isolation, lower self-esteem that complicates relationships, work performance and may lead to several other ailments.
Thus, to help these people alleviate the devastating effects of depression, let us identify some of the ways that can
It’s been a long time since we have watched the successful progression of ketamine to treat the patients suffering from psychiatric disorders. In fact, we’ve always known its effectiveness to eliminate anxiety, depression, bipolar disorder and even PTSD.
So what makes ketamine so effective and how it works in our brain?
So far many researchers have attempted to unveil this mystery. These researchers have come upon many different potential uses for IV infusions including pain relief, elimination of suicidal ideations, prevention of relapse in drug abuse and alcohol etc.
Also, little by little,
As we know ketamine is an anesthetic drug that is effectively and safely used in hospitals worldwide. The drug is now also used in sub-anesthetic dosage to treat chronic depression in people belonging to different age groups.
Before you receive the ketamine infusion therapy, there are some additional test administered by your psychiatrist to finally ascertain if you meet the exclusion/inclusion criteria. These additional tests include;
Patient Health Questionnaire-9 (PHQ-9)
The PHQ-9 is actually a 1-2 minutes brief and self-administered test. It is conducted to measure the depression severity in the patient and
Since its introduction, Transcranial Magnetic Stimulation – TMS has been tested through different studies for its efficacy in treating major depression. There are many clinical trials (more than 20) that prove this treatment to be a successful brain stimulation method.
Brain stimulation techniques are the only treatment modality that can possibly be used to treat the patients with treatment-resistant depression. This is exactly what was proven through various controlled and randomized trials which investigated the potential of rTMS to treat chronic depression.
To give you an example;
Toro, et al. studied the rTMS
The transcranial magnetic stimulation has greatly contributed to understanding the function of a normal brain. It also helps in stimulating the human brain and nerves for therapy. In other words, the growth of this non-invasive method has now fundamentally shifted the modern medicine practices!
By the use of nuclear magnetic resonance imaging to electrocardiograms, many clinicians are constantly acquiring complete and better understanding of things happening inside the human body.
This is being done without the need for surgery or having to cut open the body. With that, TMS also provides an
The nerve cells in our body are surrounded by a membrane that maintains the difference in electrical potential of -70mV between their surrounding and their interior.
When current is locally induced, it decreases this potential difference by some millivolts all along the length of the cell membrane and initiates a depolarization wave that propagates along the nerve fiber length.
This is referred as a nerve impulse.
This nerve impulse can also be generated by electrode insertion into/near the nerve and can be stimulated by providing current through the skin or electrically.
Both of these
Receiving ketamine infusion therapy is not similar to other dental or surgical procedure. The therapy involves IV ketamine. An IV is placed for a while but it is not at all painful. It has low risks of infection especially when the treatment is performed by a professional.
At the start of infusion, you don’t feel ketamine effects immediately. However, after a while, you may feel a benign tingling sensation in extremities or lips. Some patients feel as if their mind is detached from their bodies. While this may sound strange, patients
Ketamine infusion therapy is a popular treatment for treatment-resistant depression. Almost 10 – 20 percent patients undergoing depressive state meet the criteria for treatment-resistant depression – TRD.
When you take the professional assistance of a reputed psychiatrist for infusions, you must fulfill the following inclusion criteria;
Age of 18 years or older
Must have failed minimum 3 antidepressant trials
Depression severity along with duration or lack of response to conventional antidepressant should be clinically sufficient to call for ketamine treatment and not the remaining traditional options.
Suicidal ideations should be of severity to demand ketamine
There have been several clinical trials in which single low dosage (0.5mg/kg) of intravenous Ketamine (IV) is used. As per the results, ketamine successfully yielded almost 70% response rate in individuals suffering from treatment-resistant depression. The variable duration of effectiveness seems to be related to different factors such as gender, age, depression duration, and comorbidities.
So how does Ketamine IV infusion work?
Ketamine is a receptor agonist, ionotropic glutamatergic N-methyl-d-aspartate – NMDA that has been used for anesthesia. But it is also prescribed (off-label) for the treatment of chronic pain. Ketamine set
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