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Ketamine An Effective Antidepressant Against Treatment-Resistant Depression
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Ketamine: An Effective Antidepressant Against Treatment-Resistant Depression

Depression is one of that mental disorder for which medical science has failed to come with a single standard, effective therapy. For that matter, depression patients strive to find a treatment that can mitigate their condition. Some patients find solace in the use of antidepressants. Then, there are patients who combat the symptoms of depression through psychotherapy sessions.  

However, there is one unfortunate group of depression patients who can’t experience any improvement in their condition through the aforementioned conventional methods. This condition is often termed as treatment-resistant depression. Both physicians and psychiatrists are trying to devise an effective treatment regimen against treatment-resistant depression.

Ketamine as an Antidepressant

Ketamine, which was primarily formulated to provide anesthesia, has shown impressive results against the symptoms of treatment-resistant depression. It has been studied that the patients receiving IV ketamine can experience a considerable improvement in their mental state within a couple of minutes. It is important to mention here that not even the most effective conventional antidepressants can produce such quick results against the depression symptoms.

What Makes Ketamine an Instant and Effective Antidepressant?

Scientists are still trying to study the underlying mechanism of ketamine against depression symptoms. However, the preliminary studies suggest that ketamine as an antidepressant doesn’t react like customary medications.

The majority of prescription antidepressants available in the market are actually serotonin reuptake inhibitors. They actually inhibit the enzymes that deactivate serotonin, a neurotransmitter widely known as the chemical reason behind the feeling of happiness and elation.

Ketamine, on the other hand, doesn’t have the same reaction pathway in the brain as traditional serotonin reuptake inhibitors. Instead, it has a more comprehensive action that entails rebalancing of several neurotransmitters in the brain to improve mental activity in lesser time.

It has also been studied that ketamine drives G proteins (found excessively in depression patients) out of lipid rafts of neurons within minutes. This might also be the reason for the instant activity of ketamine as an antidepressant.

Advanced Psychiatric Solutions of Kansas City (APSKC) offers IV ketamine treatment sessions on an outpatient basis under the supervision of certified physicians. Patients of treatment-resistant depression immediately feel an improvement in their condition right after the first ketamine session. APSKC ensures that patients don’t experience any ketamine side effects by immaculately managing its doses through the course of the treatment.



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